Endometriosis is a manageable gynecological condition. It occurs when endometrial implants, comprised of tissue normally found within the uterus, are present in other areas of the body. As the tissue continues to thicken, break down, respond to menstrual cycle hormones, and bleed during the menstrual cycle, endometriosis forms deep inside the body. Scar tissue and adhesions form, and this can cause organ fusion and anatomical changes. Endometriosis is thought to affect around 11 percent of women in the United States aged between 15 and 44 years. What is endometriosis? Endometriosis sees the endometrial implant tissue, normally found in the uterus build up in other parts of the body. Endometrial tissue consists of gland, blood cells, and connective tissue. It normally grows in the uterus, to prepare the lining of the womb for ovulation. Endometrial implants are buildups of endometrial tissue that grow in locations outside the uterus. When they grow outside the uterus, this is called endometriosis. They can develop anywhere in the body, but they usually occur in the pelvic area. They may affect: the ovaries the fallopian tubes the peritoneum the lymph nodes Normally, this tissue is expelled during menstruation, but displaced tissue cannot do this. This leads to physical symptoms, such as pain. As the lesions grow larger, they can affect bodily functions. For example, the fallopian tubes may be blocked. The pain and other symptoms can affect different areas of life,including the ability to work, medical care costs, and difficulty maintaining relationships. Symptoms Other medical conditions such as pelvic inflammatory disease(PID),ovarian cysts, and irritable bowel syndrome(IBS) can mimic the symptoms of endometriosis. Symptoms of endometriosis include: Severe menstrual cramps, unrelieved with NSAIDS Long-term lower-back and pelvic pain Periods lasting longer than 7 days Heavy menstrual bleeding where the pad or tampon needs changing every 1 to 2 hours Bowel and urinary problems including pain,diarrhea,constipation, and bloating Bloody stool or urine Nausea and vomiting Fatigue Pain during intercourse Spotting or bleeding between periods Pain is the most common indication of endometriosis, but the severity of the pain does not always correlate with the extent of the disease. Pain often resolves following menopause, when the body stops producing estrogen production. However, if hormone therapy is used during menopause, symptoms may persist. Pregnancy may provide temporary relief from symptoms. Complications Complications include: infertility, which can affect 50 percent of those with the condition. increased risk of developing ovarian cancer or endometriosis-associated adenocarcinoma ovarian cysts inflammation scar tissue and adhesion development intestinal and bladder complications It is important to see a health care provider about symptoms, to avoid future complications. Treatment A hysterectomy, or the removal of the uterus, will be considered when all other avenues of treatment have been exhausted. Surgery is possible, but it is normally considered only if other treatments are not effective. Other options include: Pain medications: Either over-the-counter (OTC) nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil, Motrin IB, others) or prescription drugs for the treatment of painful menses. Hormones: Treatment may be with hormonal therapies such as hormonal birth control, Gonadotropin-releasing hormone (Gn-RH) agonists and antagonists, Medroxyprogesterone (Depo-Provera) or Danazol. Placement of an intrauterine device (IUD) may also be recommended. Surgery: Initial surgery will seek to remove the areas of endometriosis, but a hysterectomy with removal of both ovaries may be necessary. Fertility treatment: Pregnancy may be recommended via in-vitro fertilization (IVF). Managing symptoms at home Complementary and alternative treatments may include acupuncture, chiropractic, and herbal medicine, but there is little evidence to show that these are effective. Avoiding caffeine may help to reduce pain, as caffeine can worsen symptoms. Exercise, such as walking, may reduce pain and slow the progress of the condition by reducing estrogen levels. It is important to monitor symptoms, because of the long-term complications of endometriosis. Intolerable pain or unexpected bleeding should be reported to a doctor. Although there is currently no cure for endometriosis, most women are able to relieve the pain of symptoms and will still be able to have children. Diagnosis Diagnosis can be challenging because there is no single test for evaluation. The only way to truly confirm the condition is by undergoing a surgical laparoscopy. A surgical laparoscopy is a minimally invasive procedure in which a thin, lighted tube with a miniature camera attached, called a laparoscope, is inserted through a small incision in the pelvic area. A diagnosis can be categorized as follows: Stage 1: Lesions are minimal and isolated Stage 2: Lesions are mild. There may be several and adhesions are possible. Stage 3: Lesions are moderate, deep or superficial with clear adhesions Stage 4: Lesions are multiple and severe, both superficial and deep, with prominent adhesions. It can take many years to receive a diagnosis. Other possible diagnostic strategies include a pelvic exam, radiologic imaging with ultrasound or magnetic resonance imaging (MRI), and the use of certain medications including birth control or gonadotropin releasing hormone (GnRH) agonists. Causes Endometriosis can lead to painful cramps in the pelvis, but doctors do not understand its exact cause. The exact cause of endometriosis is not currently fully understood. Possible explanations include: Problems with menstrual flow: Menstrual blood enters the fallopian tubes and the pelvis instead of leaving the body in the usual way. Embryonic cell growth: At times, embryonic cells lining the abdomen and pelvis develop into endometrial tissue within those cavities. Fetal development: Data show that endometriosis can be present in a developing fetus, but pubertal estrogen levels are thought to trigger the symptoms. Surgical scar: Endometrial cells can move during a procedure such as a hysterectomy orc-section. Endometrial cell transport: The lymphatic system transports endometrial cells to various parts of the body. Genetics: There may be an inherited component. A woman with a close family member who has endometriosis is more likely to develop endometriosis herself. Hormones: Endometriosis is stimulated by the hormone estrogen. Immune system: Problems with the immune system can prevent the destruction of extra-uterine endometrial tissue. Risk factors Anyone can develop endometriosis, but some risk factors increase the risk. These include: Age: It is most common in women aged 30 to 40 years Nulliparity: Never giving birth Genetics: One or more relatives having the condition Medical history: Having a pelvic infection, uterine abnormalities, or a condition that prevents expulsion of menstrual blood. Menstrual history: Menses lasting more than 7 days or menstrual cycles of less than 27 days. Caffeine, alcohol consumption, and lack of exercise: These can raise levels of estrogen. Some health conditions have been linked to endometriosis. These include allergies, asthma, and some chemical sensitivities, some autoimmune diseases, chronic fatigue syndrome, and ovarian and breast cancer. Researchershave found links between endometriosis and exposure to certain chemicals, including phthalates.